کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4339779 | 1614906 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bright light produces Fos-positive neurons in caudal trigeminal brainstem
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کلمات کلیدی
FOSPBSNTSIVTVc/C1Fos-LI - FOS-LItrigeminal subnucleus interpolaris - اینترنالالری زیر هسته سه گانهintravitreal - داخل شیشهPain - دردTrigeminal subnucleus caudalis - ساب گلبول قرمز Trigeminal caudalisPhotophobia - فتو فوبیاPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریRat - موش صحراییnorepinephrine - نوراپی نفرینnucleus tractus solitarius - هسته دستگاه انفرادی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Bright light produces Fos-positive neurons in caudal trigeminal brainstem Bright light produces Fos-positive neurons in caudal trigeminal brainstem](/preview/png/4339779.png)
چکیده انگلیسی
Excessive discomfort after exposure to bright light often occurs after ocular injury and during headache. Although the trigeminal nerve is necessary for light-evoked discomfort, the mechanisms underlying this phenomenon, often referred to generally as photophobia, are not well defined. Quantitative Fos-like immunoreactivity (Fos-LI) was used to determine the pattern of neuronal activation in the caudal brainstem after bright light stimulation and, secondly, whether a neurovascular mechanism within the eye contributes to this response. Under barbiturate anesthesia, male rats were exposed to low (1Ã104 lx) or high intensity (2Ã104 lx) light delivered from a thermal neutral source for 30 min (30 s ON, 30 s OFF) and allowed to survive for 90 min. Intensity-dependent increases in Fos-LI were seen in laminae I-II at the trigeminal caudalis/cervical cord junction region (Vc/C1) and nucleus tractus solitarius (NTS). Fos-LI also increased at the trigeminal interpolaris/caudalis transition (Vi/Vcvl) and dorsal paratrigeminal (dPa5) regions independent of intensity. Intravitreal injection of norepinephrine greatly reduced light-evoked Fos-LI at the Vc/C1, dPa5 and NTS, but not at the Vi/Vc transition. Lidocaine applied to the ocular surface had no effect on Fos-LI produced in trigeminal brainstem regions. These results suggested that multiple regions of the caudal trigeminal brainstem complex integrate light-related sensory information. Fos-LI produced at the dPa5 and NTS, coupled with norepinephrine-induced inhibition, was consistent with the hypothesis that light-evoked activation of trigeminal brainstem neurons involves an intraocular neurovascular mechanism with little contribution from neurons that supply the ocular surface.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 160, Issue 4, 2 June 2009, Pages 858-864
Journal: Neuroscience - Volume 160, Issue 4, 2 June 2009, Pages 858-864
نویسندگان
K. Okamoto, R. Thompson, A. Tashiro, Z. Chang, D.A. Bereiter,