کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340091 | 1295782 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Time course of cortically induced fos expression in auditory thalamus and midbrain after bilateral cochlear ablation
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کلمات کلیدی
denervation hypersensitivityDABPBSMGMNGSCICMGDMGVDCICBicucullinediaminobenzidine tetrahydrochlorideMGBmedial geniculate body - اندام تناسلیphosphate buffer - بافر فسفاتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancenormal goat serum - سرم طبیعی بزPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریInferior colliculus - کولیکولوس پایینCochleostomy - کوهلوستومی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Expression of c-fos in the medial geniculate body (MGB) and the inferior colliculus (IC) in response to bicuculline-induced corticofugal activation was examined in rats at different time points after bilateral cochlear ablation (4 hâ30 days). Corticofugal activation was crucial in eliciting Fos expression in the MGB after cochlear ablation. The pars ovoidea (OV) of the medial geniculate body ventral division (MGv) showed dense Fos expression 4 h after cochlear ablation; the expression declined to very low levels at 24 h and thereafter. In turn, strong Fos expression was found in the pars lateralis (LV) of the MGv 24 h after cochlear ablation and dropped dramatically at 14 days. The dorsal division of the MGB (MGd) showed high Fos expression 7 days after cochlear ablation, which persisted for a period of time. Using multi-electrode recordings, neuronal activity of different MGB subnuclei was found to correlate well with Fos expressions. The temporal changes in cortically activated Fos expression in different MGB subnuclei after bilateral cochlear ablation indicate differential denervation hypersensitivities of these MGB neurons and likely point to differential dependence of these nuclei on both auditory ascending and corticofugal descending inputs. After bilateral cochlear ablation, significant increases in Fos-positive neurons were detected unilaterally in all IC subnuclei, ipsilateral to the bicuculline injection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 160, Issue 1, 21 April 2009, Pages 186-197
Journal: Neuroscience - Volume 160, Issue 1, 21 April 2009, Pages 186-197
نویسندگان
X. Sun, Y.P. Guo, D.K.-Y. Shum, Y.-S. Chan, J. He,