کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340273 | 1295789 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine
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کلمات کلیدی
PFCTTXNMDAGLT-1N-methyl-d-aspartic acidmGluR2/3 - mGluR2 / 3tetrodotoxin - تترو دوتوکسین Glutamate transporter - حمل و نقل گلوتاماتglutamate transporters - حمل و نقل گلوتاماتprefrontal cortex - قشر prefrontalmicrodialysis - میکرو دیالیزMetabotropic glutamate receptors - گیرنده های متابوتروپیک گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine](/preview/png/4340273.png)
چکیده انگلیسی
Chronic cocaine administration causes instability in extracellular glutamate in the nucleus accumbens that is thought to contribute to the vulnerability to relapse. A computational framework was developed to model glutamate in the extracellular space, including synaptic and nonsynaptic glutamate release, glutamate elimination by glutamate transporters and diffusion, and negative feedback on synaptic release via metabotropic glutamate receptors (mGluR2/3). This framework was used to optimize the geometry of the glial sheath surrounding excitatory synapses, and by inserting physiological values, accounted for known stable extracellular, extrasynaptic concentrations of glutamate measured by microdialysis and glutamatergic tone on mGluR2/3. By using experimental values for cocaine-induced reductions in cystine-glutamate exchange and mGluR2/3 signaling, and by predicting the down-regulation of glutamate transporters, the computational model successfully represented the experimentally observed increase in glutamate that is seen in rats during cocaine-seeking. This model provides a mathematical framework for describing how pharmacological or pathological conditions influence glutamate transmission measured by microdialysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 4, 18 February 2009, Pages 1266-1276
Journal: Neuroscience - Volume 158, Issue 4, 18 February 2009, Pages 1266-1276
نویسندگان
S. Pendyam, A. Mohan, P.W. Kalivas, S.S. Nair,