کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4340515 | 1295799 | 2008 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential expression of five members of the ADAM family in the developing chicken brain
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کلمات کلیدی
PBSORFTBSHEPES-buffered salt solutionRT-PCRHBSSEGFIn situ hybridization - Hybridization در محلADAM - آدامa disintegrin and metalloprotease - تخریب و متالوپروتئازTris-buffered saline - تریس بافر شورrapid amplification of cDNA ends - تقویت سریع cDNA به پایان می رسدThionine - تونینThio - تیوembryonic day - روز جنینیBlood vessel - رگ خونیepidermal growth factor - عامل رشد اپیدرمیPineal gland - غده پینه آلopen reading frame - قاب خواندن بازPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریRace - مسابقهNeuroepithelium - نوروپاتیلیومReverse transcriptase-polymerase chain reaction - واکنش زنجیره ای واکنش زنجیره ای واکنش زنجیره ایChoroid plexus - پیوند کوئیدgalactocerebroside - گالاتوکروبروزیدGalC - گالکسیoligodendrocytes - یاخته کم شاخه، الیگودندروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
ADAMs (a disintegrin and metalloprotease) are a family of trans-membrane multi-domain metalloproteases with multiple functions. So far, more than 35 ADAM family members have been identified from mammalian and nonmammalian sources. Although some functions of ADAMs have been elucidated, their expression patterns remain poorly investigated, especially during CNS development. Here, we cloned the open reading frames or full-length cDNAs of ADAM9, ADAM10, ADAM12, ADAM22 and ADAM23 from chicken embryonic brain, analyzed their evolutionary relationship, and mapped their expression in the embryonic chicken brain by in situ hybridization for the first time. In general, each of the five ADAMs shows a spatially restricted and temporally regulated expression profile. However, the types of tissues and cells, which express each of the five ADAMs, differ from each other. ADAM9 is predominantly expressed in the choroid plexus and in the ventricular layer. ADAM10 is expressed by developing blood vessels, oligodendrocytes, and subsets of neurons and brain nuclei. ADAM12 is expressed by very few brain nuclei, cerebellar Purkinje cells, restricted regions of the neuroepithelium, and some neurons in the deep tectal layers. ADAM22 expression is strong in some brain nuclei and in the pineal gland. ADAM23 is expressed by most gray matter regions and the choroid plexus. The differential expression patterns suggest that the five ADAMs play multiple and versatile roles during brain development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 157, Issue 2, 19 November 2008, Pages 360-375
Journal: Neuroscience - Volume 157, Issue 2, 19 November 2008, Pages 360-375
نویسندگان
J. Lin, J. Luo, C. Redies,