کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4340637 1295805 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Otoconin-90 deletion leads to imbalance but normal hearing: A comparison with other otoconia mutants
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Otoconin-90 deletion leads to imbalance but normal hearing: A comparison with other otoconia mutants
چکیده انگلیسی

Our sense of gravitation and linear acceleration is mediated by stimulation of vestibular hair cells through displacement of otoconia in the utricle and saccule (the gravity receptor organ). We recently showed that otoconin-90 (Oc90) deletion led to formation of giant otoconia. In the present study, we determined the extent to which the giant otoconia affected balance and gravity receptor sensory input and compared the findings with other otoconia mutants. We employed a wide spectrum of balance behavioral tests, including reaching and air-righting reflexes, gait, swimming, beam-crossing, rotorod latencies, and a direct measure of gravity receptor input, vestibular evoked potentials (VsEPs). All tests on homozygous adult mutants consistently ranked the order of imbalance as (from worst to best) Nox3het

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 153, Issue 1, 22 April 2008, Pages 289–299
نویسندگان
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