کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341234 | 1295828 | 2007 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optical mapping of spatiotemporal emergence of functional synaptic connections in the embryonic chick olfactory pathway
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کلمات کلیدی
NMDAN-methyl-d-aspartateAPVH-Hdl-2-amino-5-phosphonovaleric acid1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate - 1،1'-dioctadecyl-3،3،3 '، 3'-tetramethylindocarbocyanine perchlorate6-cyano-7-nitroquinoxaline-2, 3-dione - 6-سینو-7-نیتروکینکسالین-2، 3-دیونDiI - DIIEPSP - epspiChick embryo - جنین جوجهDevelopment - رشدvoltage-sensitive dye - رنگ حساس به ولتاژCNQX - سیانکیوایکسolfactory system - سیستم بویاییoptical recording - ضبط نوریglossopharyngeal nerve - عصب glossopharyngealvestibulocochlear nerve - عصب VestibulocochlearOlfactory nerve - عصب التهابیOptic nerve - عصب بیناییtrigeminal nerve - عصب سه گانهvagus nerve - عصب واگexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزolfactory bulb - پیاز بویایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
In order to understand the functional maturation of the CNS, it is essential to first describe the functional maturation of sensory processing. We have approached this topic by following the ontogenetic patterning of neural circuit formation related to cranial and spinal sensory input using voltage-sensitive dye imaging. In previous studies, we have described the functional maturation of synapses in brainstem/midbrain neural circuits. Here, we elucidate the functional maturation of forebrain circuits by investigating neural networks related to the olfactory nerve (N. I) of chicken embryo. In the isolated N. I-olfactory bulb-forebrain preparation, application of electrical stimulation to N. I elicited excitatory postsynaptic potential (EPSP)-related slow optical signals in the olfactory bulb. The slow signal was mainly mediated by glutamate, and was easily fatigued with repetitive stimuli because of the immaturity of synapses in the embryonic CNS. Ontogenetically, the slow signal was detected from the 6-day embryonic stage, suggesting that functional synaptic connections between N. I and olfactory bulb emerge around this stage. In addition, from the 8-day embryonic stage, another response area was discriminated within the forebrain, which corresponded to the higher-ordered nucleus of the olfactory pathway. In comparison with our previous studies concerning the functional development of other cranial nerve-related sensory nuclei in the embryonic brainstem and midbrain, these results suggest that the olfactory pathway is functionally generated in the early stages of development when neural networks related to other visceral and somatic sensory inputs are also in the process of developing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 144, Issue 4, 23 February 2007, Pages 1334-1346
Journal: Neuroscience - Volume 144, Issue 4, 23 February 2007, Pages 1334-1346
نویسندگان
K. Sato, M. Kinoshita, Y. Momose-Sato,