کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341292 | 1295830 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo
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کلمات کلیدی
NACGCsAMPARLFSNMDARHFSEPSP - epspilong-term depression - افسردگی طولانی مدتWithdrawal - برداشت از حسابhigh frequency stimulation - تحریک فرکانس بالاlow frequency stimulation - تحریک فرکانس پایینlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Acute withdrawal - خروج حادLTD - محدودNucleus accumbens - هسته accumbensHippocampus - هیپوکامپ excitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزGlucocorticoids - گلوکوکورتیکوئیدهاAMPA receptor - گیرنده AMPAN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartateNMDA receptors - گیرنده NMDAglucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Subiculum receives output of hippocampal CA1 neurons and projects glutamatergic synapses onto nucleus accumbens (NAc), the subicular-NAc pathway linking memory and reward system. It is unknown whether morphine withdrawal influences synaptic plasticity in the subicular-NAc pathway. Here, we recorded the field excitatory postsynaptic potential (EPSP) within the shell of NAc by stimulating ventral subiculum in anesthetized adult rats. We found that high frequency stimulation (HFS, 200 Hz) induced long-term potentiation (LTP) but low frequency stimulation (LFS, 1 Hz) failed to induce long-term depression (LTD) in control animals. However, behavioral stress enabled LFS to induce a reliable LTD (sLTD) that was dependent on the glucocorticoid receptors. Both LTP and sLTD were prevented by the N-methyl-d-aspartate receptor antagonist AP-5. After repeated morphine treatment for 12 days, acute withdrawal (12 h) impaired LTP but had no effect on sLTD; prolonged withdrawal (4 days) restored the LTP but impaired the sLTD. Remarkably, basal synaptic efficacy reflected by baseline EPSP amplitude was potentiated in acute withdrawal but was depressed in prolonged withdrawal. Thus, acute and prolonged opiate withdrawal may cause endogenous LTP and LTD in the subicular-NAc pathway that occludes the subsequent induction of synaptic plasticity, demonstrating adaptive changes of the NAc functions during opiate withdrawal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 144, Issue 3, 9 February 2007, Pages 845-854
Journal: Neuroscience - Volume 144, Issue 3, 9 February 2007, Pages 845-854
نویسندگان
Z. Dong, J. Cao, L. Xu,