کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341434 | 1295834 | 2006 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The local loop of the saccadic system closes downstream of the superior colliculus
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کلمات کلیدی
PDBnucleus reticularis tegmenti pontisLLBNRTPMLBEPEomnipause neuronCATOPNmotoneuronRPOΔEE′ - E 'neural integrator - انتگرال عصبیBurst generator - انفجار ژنراتورFOR - برایElectrical stimulation - تحریک الکتریکیSuperior colliculus - ستارگان برترparamedian pontine reticular formation - شکل گیری رتیکولین پونتین پارامدیprepositus hypoglossi - عصب زیر زبانی شهردارChemical inactivation - غیر فعال سازی شیمیاییEye position - موقعیت چشمnucleus reticularis pontis oralis - پل دهان هسته
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The local loop of the saccadic system closes downstream of the superior colliculus The local loop of the saccadic system closes downstream of the superior colliculus](/preview/png/4341434.png)
چکیده انگلیسی
Models of the saccadic system differ in several respects including the signals fed back to their comparators, as well as the location and identity of the units that could serve as comparators. Some models place the comparator in the superior colliculus while others assign this role to the reticular formation. To test the plausibility of reticular models we stimulated electrically efferent fibers of the superior colliculus (SC) of alert cats along their course through the pons, in the predorsal bundle (PDB). Our data demonstrate that electrical stimulation of the PDB evokes saccades, even with stimuli of relatively low frequency (100 Hz), which are often accompanied by slow drifts. The velocity and latency of saccades are influenced by the intensity and frequency of stimulation while their amplitude depends on the intensity of stimulation and the initial position of the eyes. The dynamics of evoked saccades are comparable to those of natural, self-generated saccades of the cat and to those evoked in response to the electrical stimulation of the SC. We also show that PDB-evoked saccades are not abolished by lesions of the SC and that therefore antidromic activation of the SC is not needed for their generation. Our data clearly demonstrate that the burst generator of the horizontal saccadic system is located downstream of the SC. If it is configured as a local loop controller, as assumed by most models of the saccadic system, our data also demonstrate that its comparator is located beyond the decussation of SC efferent fibers, in the pons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 143, Issue 1, 17 November 2006, Pages 319-337
Journal: Neuroscience - Volume 143, Issue 1, 17 November 2006, Pages 319-337
نویسندگان
R. Kato, A. Grantyn, Y. Dalezios, A.K. Moschovakis,