کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4341480 1295837 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dexamethasone transiently attenuates up-regulation of endostatin/collagen XVIII following traumatic brain injury
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Dexamethasone transiently attenuates up-regulation of endostatin/collagen XVIII following traumatic brain injury
چکیده انگلیسی
Endostatin/collagen XVIII is a specific inhibitor of endothelial proliferation and migration in vitro. It has also been shown to have anti-angiogenic activity and tumor growth inhibitory activity in vivo and in vitro. Here we studied expression of endostatin/collagen XVIII in a rat traumatic brain injury (TBI) model, focusing on the early phase. A significant up-regulation of endostatin/collagen XVIII in TBI began as early as 24 h post-TBI. Double-staining experiment revealed that the major resource of endostatin/collagen XVIII+ cells in our TBI rat model was a subpopulation of reactivated microglia/macrophages. Our data further showed that dexamethasone attenuated up-regulation of endostatin/collagen XVIII expression at days 1 and 2, but not at day 4, post-TBI, indicating that dexamethasone might possess an early and transient influence to the angiogenesis following TBI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 147, Issue 3, 13 July 2007, Pages 720-726
نویسندگان
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