کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341496 | 1295838 | 2006 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased apoptosis in rat brain after rapid eye movement sleep loss
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کلمات کلیدی
DABIgGFITC3,3′diaminobenzidineDPXFMCLPCLDTBcl-2/Bax - Bcl-2 / Baximmunoglobulin - ایمونوگلوبولینanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTUNEL - تونلlaterodorsal tegmentum - تیرانداز بعدیfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتlocus coeruleus - لوکوس سیرولئوسREM sleep deprivation - محرومیت از خواب REMElectron microscopy - میکروسکوپ الکترونیHoechst - هوچستcytoskeletal proteins - پروتئین های سیتو اسکلتی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased apoptosis in rat brain after rapid eye movement sleep loss Increased apoptosis in rat brain after rapid eye movement sleep loss](/preview/png/4341496.png)
چکیده انگلیسی
Rapid eye movement (REM) sleep loss impairs several physiological, behavioral and cellular processes; however, the mechanism of action was unknown. To understand the effects of REM sleep deprivation on neuronal damage and apoptosis, studies were conducted using multiple apoptosis markers in control and experimental rat brain neurons located in areas either related to or unrelated to REM sleep regulation. Furthermore, the effects of REM sleep deprivation were also studied on neuronal cytoskeletal proteins, actin and tubulin. It was observed that after REM sleep deprivation a significantly increased number of neurons in the rat brain were positive to apoptotic markers, which however, tended to recover after the rats were allowed to undergo REM sleep; the control rats were not affected. Further, it was also observed that REM sleep deprivation decreased amounts of actin and tubulin in neurons confirming our previous reports of changes in neuronal size and shape after such deprivation. These findings suggest that one of the possible functions of REM sleep is to protect neurons from damage and apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 142, Issue 2, 13 October 2006, Pages 315-331
Journal: Neuroscience - Volume 142, Issue 2, 13 October 2006, Pages 315-331
نویسندگان
S. Biswas, P. Mishra, B.N. Mallick,