کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341520 | 1295838 | 2006 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of synaptic input to hypothalamic presympathetic neurons by GABAB receptors
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کلمات کلیدی
GDP-β-SN-ethylmaleimideQX-314aCSFsIPSCssEPSCsIMLmEPSCsmIPSCsGIRKSNARE6-Cyano-7-nitroquinoxaline-2,3-dione - 6-Cyano-7-nitroquinoxaline-2،3-dioneEPSC - EPSCoRguanosine 5′-O-(2-thiodiphosphate) - guanosine 5'-O- (2-thiodiphosphate)synaptic transmission - انتقال سیناپسیBrain slices - برش مغزminiature inhibitory postsynaptic currents - جریان ممانعت کننده پسینپتیکspontaneous excitatory postsynaptic currents - جریان های پسینپتیک هیجان انگیز خودبهخودیexcitatory postsynaptic current - جریان پستیینپتیک تحریک کنندهSpontaneous inhibitory postsynaptic currents - جریانهای پسینپتیک مهار کننده خود به خودیminiature excitatory postsynaptic currents - جریانهای پسینپتیک هیجان انگیز مینیاتوریintermediolateral cell column - ستون سلول میان سلولیCNQX - سیانکیوایکسShr - شریPVN - مالیات بر ارزش افزودهartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیpresynaptic modulation - مدولاسیون پیش فرضSpontaneous hypertensive rat - موش های فشارخون خود به خودیNEM - نهparaventricular nucleus - هسته پروژسترویکHypothalamus - هیپوتالاموسVoltage-gated K+ channels - کانال های K + دارای ولتاژ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The hypothalamic paraventricular (PVN) neurons projecting to the spinal cord and brainstem play an important role in the control of homeostasis and the sympathetic nervous system. Although GABAB receptors are present in the PVN, their function in the control of synaptic inputs to PVN presympathetic neurons is not clear. Using retrograde tracing and whole-cell patch-clamp recordings in rat brain slices, we determined the role of presynaptic GABAB receptors in regulation of glutamatergic and GABAergic inputs to spinally projecting PVN neurons. The GABAB receptor agonist baclofen (1-50 μM) dose-dependently decreased the frequency but not the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) and inhibitory postsynaptic currents (sIPSCs). The effect of baclofen on sEPSCs and sIPSCs was completely blocked by 10 μM CGP52432, a selective GABAB receptor antagonist. Baclofen also significantly reduced the frequency of both miniature excitatory and miniature inhibitory postsynaptic currents (mEPSCs and mIPSCs). Furthermore, uncoupling pertussis toxin-sensitive Gi/o proteins with N-ethylmaleimide abolished baclofen-induced inhibition of mEPSCs and mIPSCs. However, the inhibitory effect of baclofen on the frequency of mIPSCs and mEPSCs persisted in the presence of either Cd2+, a voltage-gated Ca2+ channel blocker, or 4-aminopyridine, a blocker of voltage-gated K+ channels. Our results suggest that activation of presynaptic GABAB receptors inhibits synaptic GABA and glutamate release to PVN presympathetic neurons. This presynaptic action of GABAB receptors is mediated by the N-ethylmaleimide-sensitive Gi/o proteins, but independent of voltage-gated Ca2+ and K+ channels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 142, Issue 2, 13 October 2006, Pages 595-606
Journal: Neuroscience - Volume 142, Issue 2, 13 October 2006, Pages 595-606
نویسندگان
Q. Chen, H.-L. Pan,