کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341621 | 1295841 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Isoniazid-induced reduction in GABAergic neurotransmission alters the function of the cerebellar cortical circuit
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
INHethyleneglycol-bis-(β-aminoethyl ether) N,N,N′,N′-tetraacetic acidmIPSCeIPSCaCSFMPAGADEGTACFSHEPES4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid - 4- (2-Hydroxyethyl) piperazine-1-ethanesulfonic acidEPSP - epspiglutamic acid decarboxylase - glutamic acid dearboxylase3-Mercaptopropionic acid - اسید 3-مروپپروپرونیکisoniazid - ایزونیازیدexcitability - تحریک پذیریminiature inhibitory postsynaptic current - جریان ممانعت کننده پستانیپتیک مینیاتوریCerebrospinal fluid - مایع مغزی نخاعیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیCerebellum - مخچهevoked inhibitory postsynaptic current - موجب شده است که جریان پستانی پات را مهار کندSynapse - همایه یا سیناپسIsonicotinic acid hydrazide - هیدرازید سدیم اسونیکوتینexcitatory postsynaptic potential - پتانسیل پست سیناپتی هیجان انگیزGABA - گاباGABAA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Isoniazid-induced reduction in GABAergic neurotransmission alters the function of the cerebellar cortical circuit Isoniazid-induced reduction in GABAergic neurotransmission alters the function of the cerebellar cortical circuit](/preview/png/4341621.png)
چکیده انگلیسی
The cerebellar cortex contributes to the control of movement, coordination, and certain cognitive functions. The cerebellar network is composed of five different types of neurons that are wired together in a repetitive module. Given that four of these five neurons synthesize and release GABA, this inhibitory neurotransmitter plays a central role in regulation of the excitability and correct functioning of the cerebellar cortex. We have now used isoniazid, an inhibitor of glutamic acid decarboxylase, the enzyme responsible for the synthesis of GABA, to evaluate the contribution of GABAergic transmission in different types of cerebellar cortical neurons to the functioning of the cerebellar circuit. Parasagittal cerebellar slices were prepared from 28- to 40-day-old male rats and were subjected to patch-clamp recording in the voltage- or current-clamp mode. Exposure of the tissue slices to isoniazid (10 mM) resulted in a decrease in the level of GABAergic transmission in Purkinje cells and a consequent increase in the firing rate of spontaneous action potentials that was apparent after 40 min. In granule neurons, isoniazid reduced both tonic and phasic GABAergic currents and thereby altered the flow of information across the cerebellar cortex. Our data support the notion that the amount of GABA at the synaptic level is a major determinant of the excitability of the cerebellar cortex, and they suggest that isoniazid may be a useful tool with which to study the function of the cerebellar network.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 154, Issue 2, 23 June 2008, Pages 710-719
Journal: Neuroscience - Volume 154, Issue 2, 23 June 2008, Pages 710-719
نویسندگان
M. Carta, L. Murru, E. Barabino, G. Talani, E. Sanna, G. Biggio,