کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4342013 | 1295853 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal
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کلمات کلیدی
CPPROIMEMRIOFCManganese-enhanced MRI - MRI پیشرفته منگنزelectroencephalograph - الکتروانسفالوگرافیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceconditioned place preference - ترجیح محل موظف استMagnetic resonance - تشدید مغناطیسیmanganese-enhanced magnetic resonance imaging - تصویربرداری رزونانس مغناطیسی با افزایش منگنزmediolateral - دو طرفهorbitofrontal cortex - قشر اوربیتوفرنتالregion of interest - منطقه مورد نظرDrug craving - میل به مواد مخدرEEG - نوار مغزیanteroposterior - پیشاپیش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl2 (200nL, 80mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20-100Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 138, Issue 1, 2006, Pages 77-82
Journal: Neuroscience - Volume 138, Issue 1, 2006, Pages 77-82
نویسندگان
N. Sun, Y. Li, S. Tian, Y. Lei, J. Zheng, J. Yang, N. Sui, L. Xu, G. Pei, F.A.W. Wilson, Y. Ma, H. Lei, X. Hu,