کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4342049 | 1295854 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Estrogen therapy: Does it help or hurt the adult and aging brain? Insights derived from animal models
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کلمات کلیدی
MCATTCOVXovariectomizedEstrogen - استروژنEstrogen Therapy - استروژن درمانIschemia - ایسکمیTriphenyltetrazolium chloride - ترفتhenyltetrazolium chlorideStroke - سکته مغزیmiddle cerebral artery - شریان مغزی میانیNeuroprotection - محافظت نورونی یا محافظت از عصبCell death - مرگ سلولی Estrogen receptor - گیرنده استروژنMenopause - یائسگی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Our laboratory has shown that physiological levels of estradiol attenuate ischemic brain injury in young and middle-aged female rats. We have begun to probe the cellular and molecular mechanisms that underlie these novel non-reproductive actions of this steroid. Our findings demonstrate that in both young and aging rats, treatment with physiological concentrations of estradiol decreases ischemic injury by almost 50%, compared with oil-treated controls. Additionally, our data suggest that estradiol acts by altering the expression of genes that suppress apoptosis and enhance survival in the penumbral region of the infarct. These observations demonstrate that estrogen therapy protects against stroke-related injury in young and aging female rats and strongly suggest that middle-aged animals remain responsive to the protective actions of estradiol. Furthermore, they suggest that estrogen therapy protects against cell death by influencing the expression of genes that suppress apoptotic cell death pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 138, Issue 3, 27 March 2006, Pages 831-835
Journal: Neuroscience - Volume 138, Issue 3, 27 March 2006, Pages 831-835
نویسندگان
P.M. Wise,