کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4342099 | 1295857 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurotensin selectively facilitates glutamatergic transmission in globus pallidus
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کلمات کلیدی
HEPESethyleneglycol-bis-(β-aminoethyl ether)N,N,N′,N′-tetraacetic acidSR48692SR142948AmIPSCU73122mEPSCIPSCAP56-OHDApostsynaptic currentsEGTA6-HydroxydopamineTTXaCSF4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid - 4- (2-Hydroxyethyl) piperazine-1-ethanesulfonic acidEPSC - EPSCoRtetrodotoxin - تترو دوتوکسین miniature inhibitory postsynaptic current - جریان ممانعت کننده پستانیپتیک مینیاتوریinhibitory postsynaptic current - جریان پستانیپتیک مهارکنندهexcitatory postsynaptic current - جریان پستیینپتیک تحریک کنندهminiature excitatory postsynaptic current - جریان پستیینپتیک مضر تحریک آمیزCNQX - سیانکیوایکسartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیneurotensin - نوروتنسینGlobus pallidus - گوی رنگ پریده، گلوبوس پالیدوس
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The tridecapeptide neurotensin has been demonstrated to modulate neurotransmission in a number of brain regions. There is evidence that neurotensin receptors exist in globus pallidus presynaptically and postsynaptically. Whole-cell patch-clamp recordings were used to investigate the modulatory effects of neurotensin on glutamate and GABA transmission in this basal ganglia nucleus in rats. Neurotensin at 1 μM significantly increased the frequency of glutamate receptor-mediated miniature excitatory postsynaptic currents. In contrast, neurotensin had no effect on GABAA receptor-mediated miniature inhibitory postsynaptic currents. The presynaptic facilitation of neurotensin on glutamatergic transmission could be mimicked by the C-terminal fragment, neurotensin (8-13), but not by the N-terminal fragment, neurotensin (1-8). The selective neurotensin type-1 receptor antagonist, SR48692 {2-[(1-(7-chloro-4-quinolinyl)-5-2(2,6-dimethoxyphenyl)pyrazol-3-yl)carbonylamino]-tricyclo(3.3.1.1.3.7)-decan-2-carboxylic acid}, blocked this facilitatory effect of neurotensin, and which itself had no effect on miniature excitatory postsynaptic currents. The specific phospholipase C inhibitor, U73122 {1-[6-[[17β-3-methoyyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione}, significantly inhibit neurotensin-induced facilitation on glutamate release. Taken together with the reported postsynaptic depolarization of neurotensin in globus pallidus, it is suggested that neurotensin excites the globus pallidus neurons by multiple mechanisms which may provide a rationale for further investigations into its involvement in motor disorders originating from the basal ganglia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 141, Issue 4, 2006, Pages 1871-1878
Journal: Neuroscience - Volume 141, Issue 4, 2006, Pages 1871-1878
نویسندگان
L. Chen, K.K.L. Yung, W.H. Yung,