کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4342411 1295866 2006 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational and in vitro studies of persistent activity: Edging towards cellular and synaptic mechanisms of working memory
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Computational and in vitro studies of persistent activity: Edging towards cellular and synaptic mechanisms of working memory
چکیده انگلیسی

Persistent neural activity selective to features of an extinct stimulus has been identified as the neural correlate of working memory processes. The precise nature of the physiological substrate for this self-sustained activity is still unknown. In the last few years, this problem has gathered experimental together with computational neuroscientists in a quest to identify the cellular and network mechanisms involved. I introduce here the attractor theory framework within which current persistent activity computational models are built, and I then review the main physiological mechanisms that have been linked thereby to persistent activity and working memory. Open computational and physiological issues with these models are discussed, together with their potential experimental validation in current in vitro models of persistent activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 139, Issue 1, 28 April 2006, Pages 135–151
نویسندگان
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