کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343189 1615073 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of intermittent hypoxia on arcuate nucleus in the leptin-deficient rat
ترجمه فارسی عنوان
اثر هیپوکسیا متناوب بر روی هسته قوس در موش صحرایی با کمبود لپتین
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• IH increased plasma concentration of leptin and angiotensin II in wild type rats.
• IH reduced body weight, food intake, and locomotor pattern in wild type rats.
• IH increased pSTAT3 and POMC protein expression ARC in wild type rats.
• IH did not elicit these effects in leptin-deficient rats.

Intermittent hypoxia (IH) is a major pathophysiological consequence of obstructive sleep apnea. Recently, it has been shown that IH results in changes in body energy balance, leptin secretion and concomitant alterations in arcuate nucleus (ARC). In this study, the role of leptin on these changes was investigated in leptin-deficient rats exposed to IH or normoxic control conditions. Body weights, consumatory and locomotor behaviours, and protein signaling in ARC were assessed immediately after IH exposure. Compared to normoxia, IH altered body weight, food intake, locomotor pattern, and the plasma concentration of leptin and angiotensin II in the wild-type rat. However, these changes were not observed in the leptin-deficient rat. Within ARC of wild-type animals, IH increased phosphorylated signal transducer and activator of transcription 3 and pro-opiomelanocortin protein expression, but not in the leptin-deficient rat. The long-form leptin receptor protein expression was not altered following IH in either rat strain. These data suggest that leptin is involved in mediating the alterations to body energy balance and ARC activity following IH.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 626, 28 July 2016, Pages 112–118
نویسندگان
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