کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343223 1615070 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of acute imipramine administration on the pattern of forced swim-induced c-Fos expression in the mouse brain
ترجمه فارسی عنوان
تأثیر تجویز حاد ایمی پرامین بر الگوی بیان سی-فوز ناشی از شنا ناشی از شنا در مغز موش
کلمات کلیدی
ضد افسردگی، منطقه تهاجمی هسته متقاطع
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Forced swim stress for mice increased c-Fos in hypothalamus and brain stem.
• Swim-induced c-Fos increased in additional regions after imipramine treatment.
• Forced swim test for rats and mice may reflect different aspect of antidepressants.

The forced swim test (FST) has been widely used for the preclinical evaluation of antidepressant drugs. Despite considerable differences in the protocol, equivalence of the FST for rats and mice has been rarely questioned. Previous research on the FST for rats revealed that repeated administration of antidepressant drugs attenuates the c-Fos response to swim stress in the hypothalamus and limbic regions. However, few studies have made similar investigations using the FST for mice. In the present study, we explored the mouse brain through immunohistochemistry staining for c-Fos after acute administration of imipramine or saline with or without a subsequent swim session. Imipramine enhanced the c-Fos density in regions of the central extended amygdala, while forced swim stress increased c-Fos expression in some hypothalamic (the ventrolateral preoptic nucleus and dorsomedial nucleus) and brain stem regions, which is consistent with previous reports. In contrast to previous literature with rats, swim stress brought a significant increase in c-Fos expression in the lateral septal nucleus and some other regions in the hypothalamus (the intermediate hypothalamic area, the paraventricular and arcuate nucleus) only in the imipramine-pretreated group, which has not been observed previously. In the arcuate nucleus, double immunostaining revealed that c-Fos was rarely co-expressed with proopiomelanocortin or tyrosine hydroxylase regardless of imipramine treatment. The present results suggest that the activation of several regions in the lateral septum and the hypothalamus underlies antidepressant-like effect in the mouse FST.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 629, 26 August 2016, Pages 119–124
نویسندگان
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