کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4343319 | 1615091 | 2015 | 6 صفحه PDF | دانلود رایگان |
• Taurine activated glycine receptors on preoptic hypothalamic area neurons and responses were action potential independent.
• Taurine activated homo- and hetro-meric glycine receptors on preoptic hypothalamic area neurons.
• At higher concentration taurine activated GABAA receptors on preoptic hypothalamic area neurons.
Taurine is an essential amino-sulfonic acid having a fundamental function in the brain, participating in both cell volume regulation and neurotransmission. Using a whole cell voltage patch clamp technique, the taurine-activated neurotransmitter receptors in the preoptic hypothalamic area (PHA) neurons were investigated. In the first set of experiments, different concentrations of taurine were applied on PHA neurons. Taurine-induced responses were concentration-dependent. Taurine-induced currents were action potential-independent and sensitive to strychnine, suggesting the involvement of glycine receptors. In addition, taurine activated not only α-homomeric, but also αβ-heteromeric glycine receptors in PHA neurons. Interestingly, a low concentration of taurine (0.5 mM) activated glycine receptors, whereas a higher concentration (3 mM) activated both glycine and gamma-aminobutyric acid A (GABAA) receptors in PHA neurons. These results suggest that PHA neurons are influenced by taurine and respond via glycine and GABAA receptors.
Journal: Neuroscience Letters - Volume 608, 3 November 2015, Pages 51–56