کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343370 1615098 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dendritic spine alterations in schizophrenia
ترجمه فارسی عنوان
تغییرات ستون فقرات دندریتیک در اسکیزوفرنیا
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Schizophrenia is a neurodevelopment disorder with multiple contributing genes.
• Dendritic impairments, including spine loss, are present in schizophrenia.
• Identification of conserved underlying molecular pathologies is ongoing.

Schizophrenia is a chronic illness affecting approximately 0.5–1% of the world’s population. The etiology of schizophrenia is complex, including multiple genes, and contributing environmental effects that adversely impact neurodevelopment. Nevertheless, a final common result, present in many subjects with schizophrenia, is impairment of pyramidal neuron dendritic morphology in multiple regions of the cerebral cortex. In this review, we summarize the evidence of reduced dendritic spine density and other dendritic abnormalities in schizophrenia, evaluate current data that informs the neurodevelopment timing of these impairments, and discuss what is known about possible upstream sources of dendritic spine loss in this illness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 601, 5 August 2015, Pages 46–53
نویسندگان
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