کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
4343470 1615101 2015 6 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Neural tissue regeneration in experimental brain injury model with channeled scaffolds of acrylate copolymers
ترجمه فارسی عنوان
بازسازی بافت عصبی در مدل آسیب مغزی تجربی با داربست های کانال دار از کوپلیمرهای اکریلات
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
سفارش ترجمه تخصصی
با تضمین قیمت و کیفیت
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Implanted biomaterials after experimental brain injury become colonized by host local neurons, glia, and endothelial cells.
• The copolymer p(EA-co-HEA) scaffold acts as a physical support enabling cell infiltration from host tissue after experimental brain injury.
• The glial scar (GFAP positive cells) is moderate after 8 weeks.
• There are new vessels into the implant and between tissue and scaffold.
• This is promising for clinical applications in central nervous system damage.

The objective of the present study was to evaluate the biocompatibility and cell hosting ability of a copolymer scaffold based on ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA) in vivo after an experimental brain injury. Wistar rats were subjected to cryogenic traumatic brain injury. We evaluated the tissue response to the implanted materials after 8 weeks. The materials were implanted devoid of cells; they provoked a minimal scar response by the host tissue and permitted the invasion of neurons and glia inside them. We also found new blood vessels surrounding and inside the implant. Thus, the copolymer scaffold proves to offer a suitable environment producing a cellular network potentially useful in brain repair after brain injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 598, 26 June 2015, Pages 96–101
نویسندگان
, , , , , ,
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
سفارش ترجمه تخصصی
با تضمین قیمت و کیفیت