کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343535 1615106 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain morphometry and electrophysiological recordings in relation to illness duration in schizophrenia
ترجمه فارسی عنوان
مورفومتری مغزی و ضبط الکتروفیزیولوژیک در ارتباط با مدت بیماری در اسکیزوفرنیا
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• A significant reduction in the GFP value of the N1P2 component of the AEP was detected in the schizophrenia group.
• Duration of disease increases, the GFP was found to be significantly decreased.
• Low reduced AEP voltage values correlated with reduced volumetric values in the schizophrenia group.

Schizophrenia has been recently increasingly linked with a number of structural brain morphological changes which can be associated with functional deficiencies. The aim of this study is to relate electrophysiological changes with structural changes of Heschl’s gyrus (HG) volume in schizophrenia. Fifteen schizophrenia patients were compared with control group by magnetic resonance imaging (MRI) volumetry and auditory evoked potentials. A significantly lower bilateral HG volumes and a significantly lower global field power value of the N1P2 component were detected in the schizophrenia group. The auditory evoked potentials have been used as a functional correlate that displayed a significant amplitude reduction that matched the reduction in the HG volume with the chronicity of the disease. This trend may be utilized as a vehicle to assess follow-up of the disorder by means of MRI and electrophysiology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 593, 23 April 2015, Pages 118–123
نویسندگان
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