Time up and go task performance improves after transcranial direct current stimulation in patient affected by Parkinson's disease

• Anodal transcranial direct current stimulation (AtDCS) could enhance motor performance.
• Locomotor disturbances represent one of the major distress in Parkinson's disease.
• AtDCS can be a relevant tool to modulate walking abilities in PD.
• tDCS should be considered a useful tool for patients with neurodegenerative diseases.

Locomotor disturbances represent one of the major distress in everyday life in people with Parkinson's disease (PD). Timed up and go test (TUG) has been advocated a useful and reliable tool for quantifying locomotor performance. The aim of this study was to assess the effect of anodal transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) during timed up and go test (TUG) in a group of patients with PD. Ten participants underwent two sessions of anodal tDCS (left and right) and one session of placebo tDCS. TUG was performed before and after each tDCS session (anodal or placebo). A significant motor improvement after right DLPFC stimulation vs. placebo stimulation was observed. These results suggest that anodal tDCS can be a relevant tool to modulate walking abilities in PD.