کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343661 1615121 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blockade of orexin type-1 receptors in locus coeruleus nucleus attenuates the development of morphine dependency in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Blockade of orexin type-1 receptors in locus coeruleus nucleus attenuates the development of morphine dependency in rats
چکیده انگلیسی
The aim of this study was to evaluate the effects of orexin type-1 receptor (OX1R) antagonism in locus coeruleus (LC) nucleus on the development of morphine physical dependence in rats. Animals were rendered dependent on morphine by subcutaneous (s.c.) administration of morphine sulfate (6, 16, 26, 36, 46, 56 and 66 mg/kg, 2 ml/kg) at set intervals of 24 h for 7 days. Immediately before each morphine administration, the animals received intra-LC administration of SB-334867 (3 mM, 0.2 μl), a selective orexin type-1 receptor antagonist. On day 8, naloxone (3 mg/kg, i.p.) was injected and physical dependence was evaluated for 30 min. Our results showed that administration of OX1R antagonist before each morphine injection significantly decreased somatic signs of naloxone-induced morphine withdrawal syndrome, including defecation, wet-dog shake, diarrhea, jumping, scratching, and teeth chattering. These results suggest that the activation of OX1R in LC nucleus might be involved in the development of morphine dependency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 578, 22 August 2014, Pages 90-94
نویسندگان
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