کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4343945 | 1615144 | 2013 | 5 صفحه PDF | دانلود رایگان |

• Phasic nicotinic potentiation of frog retinotectal transmission has been induced.
• It led to a facilitation of eliciting of higher activity level of the tectum column.
• This can be considered as mechanism of vigilance and cue detection.
• Thus, behavioral significance of nicotinic modulation has been demonstrated.
Nicotinic acetylcholine receptors contribute to the mediation of cholinergic role in attention, vigilance, orienting and detection of behavioral significant stimuli. We have recently demonstrated an increase of the intrinsic recurrent excitatory activity of the tectum column caused by the phasic (after-burst) nicotinic potentiation of a frog single axon retinotectal transmission to the tectum layer F. We have shown in the present study that the phasic nicotinic potentiation facilitates eliciting of higher activity level of the tectum column featured by generation of output signals from the tectum column. Since these signals can lead to an escape from danger reactions, a functional significance of nicotinic modulation of the neural network has been demonstrated. The phasic nicotinic potentiation that facilitates eliciting of higher activity level of the tectum column can be considered as a mechanism of vigilance and cue detection at the level of small neural network.
Journal: Neuroscience Letters - Volume 554, 25 October 2013, Pages 1–5