کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343947 1615144 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Contribution of muscarinic M1 receptors to the cholinergic suppression of synaptic responses in layer II of the entorhinal cortex
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Contribution of muscarinic M1 receptors to the cholinergic suppression of synaptic responses in layer II of the entorhinal cortex
چکیده انگلیسی
The entorhinal cortex is thought to play roles in sensory and mnemonic function, and the cholinergic suppression of the strength of synaptic inputs is likely to have important impacts on these processes. Field excitatory postsynaptic potentials (fEPSPs) in the medial entorhinal cortex evoked by stimulation of the piriform cortex are suppressed during theta EEG activity in behaving animals, and cholinergic receptor activation suppresses synaptic responses both in vivo, and in layer II entorhinal neurons in vitro. Here, we have used in vitro field potential recordings to investigate the transmitter receptors that mediate the cholinergic suppression of synaptic responses in layer I inputs to layer II of the medial entorhinal cortex. Bath-application of the cholinergic agonist carbachol suppressed the amplitude of fEPSPs with an EC50 of 5.3 μM, and enhanced paired-pulse ratio. The M2/M4 preferring receptor blocker methoctramine, or the M4 receptor blocker PD102807, did not prevent the cholinergic suppression. However, the M1/M4 receptor blocker pirenzepine and the M1 receptor blocker VU0255035 reduced the suppression, suggesting that the cholinergic suppression of synaptic responses in the entorhinal cortex is dependent in large part on activation of M1 receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 554, 25 October 2013, Pages 11-15
نویسندگان
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