کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4343955 1615144 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Repeated resveratrol treatment attenuates methamphetamine-induced hyperactivity and [3H]dopamine overflow in rodents
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Repeated resveratrol treatment attenuates methamphetamine-induced hyperactivity and [3H]dopamine overflow in rodents
چکیده انگلیسی
Resveratrol (3,4′,5-trihydroxy-trans-stilbene) has been investigated for its potential as a prophylactic against degenerative diseases. It is a sirtulin activator that has recently been shown to regulate dopaminergic systems that contribute to the behavioral effects of methamphetamine and cocaine. The present study examined the impact of resveratrol on stimulant neuropsychopharmacology in rodents. Acute resveratrol treatment (20-40 mg/kg) was ineffective to alter methamphetamine (0.5 mg/kg)-induced hyperactivity in mice. Rodents received resveratrol once-daily for seven days to determine the effect of repeated polyphenolic treatment. Repeated resveratrol treatment (1-20 mg/kg) decreased methamphetamine (0.5 mg/kg)-induced hyperactivity in mice. Methamphetamine's (0.1-60 μM) efficacy to evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine was also attenuated by repeated resveratrol (1 mg/kg) treatment. Repeated resveratrol treatment (10-20 mg/kg) did not affect cocaine-induced hyperactivity in mice. Overall, these data suggest that resveratrol appears to have metaplastic and prophylactic activity to minimize the effects of methamphetamine to increase locomotor activity and evoke dopamine release. These data encourage future research to further investigate the relationship between polyphenolics and psychostimulant abuse and dependence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 554, 25 October 2013, Pages 53-58
نویسندگان
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