Study on the expression of c-Fos protein in the brain of rats after ingestion of food rich in lycopene

► Lycopene contained in tomato belongs to carotenoid such as beta-carotene. ► Continuous intake of lycopene-rich food induced accumulation of lycopene in the plasma and liver. ► Continuous intake of lycopene-rich food induced the stimulation of neurons in the hypothalamus. ► Continuous intake of lycopene-rich food induced expression of c-Fos in the PVH, VMH and SO.