Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors

► Spinal 5-HT and adenosine receptors are involved in antinociception by acetaminophen. ► Peripheral adenosine A1 receptors are involved in peripheral actions of acetaminophen. ► Peripheral adenosine A1 receptors also contribute to systemic actions of acetaminophen.