Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137

► We investigated the clinical symptom profiles of carriers of the schizophrenia mir137 risk allele. ► The sample included 821 patients with schizophrenia, schizoaffective disorder and bipolar I disorder. ► Risk allele carriers had lower scores for positive symptoms and less psychosis incongruity. ► On neurocognitive testing in a subset, there were more cognitive deficits in risk allele carriers.