Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive-compulsive disorder

► Excessive self-grooming is considered as an animal model of obsessive-compulsive disorder (OCD). ► mCPP induced excessive self-grooming in the rat. ► Crocins attenuated this effect of mCPP. ► Crocins effects cannot be attributed to changes in locomotor activity. ► Crocins might play a role in OCD.