The TAT peptide endows PACAP with an enhanced ability to traverse bio-barriers

► The novel recombinant fusion peptide PACAP-TAT was constructed. ► PACAP-TAT activated the PACAP-specific receptor PAC1 like PACAP. ► PACAP-TAT traversed blood barriers more efficiently than PACAP. ► PACAP-TAT inhibited food intake more effectively than PACAP.