DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: Association and gene-gene interaction study in a population of Central Italy

► DRD2/ANKK1 TaqIA (rs1800497), SLC6A3 40 bp-VNTR SNP and gene-gene interaction analysis. ► 560 alcoholic and control AD patients from a population of Central Italy. ► SLC6A3 40 bp 3′UTR-VNTR displays no association with AD. ► DRD2/ANKK1 TaqIA genotype distribution is significantly associated to AD. ► Gene-gene interaction analysis yielded no significant result.