Rapid eye movement sleep deprivation modulates synapsinI expression in rat brain

► REMSD is reported to elevate neurotransmitter, including noradrenalin, in the brain. ► Phosphorylation of synapsinI holds key to neurotransmitter release. ► REMSD increased synapsinI, total and its phospho-form, synapsinI-phosphoSer603. ► Findings explain intracellular mechanism of REMSD associated increased neurotransmitter release.