کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4344695 1296674 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus
چکیده انگلیسی

The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy and prevented by exogenous glucocorticoid. The aim of this study was to investigate the regulation of TMT neuroxicity by corticosterone receptors including type I (mineralocorticoid receptor, MR) and type II (glucocorticoid receptor, GR) in adult mice. The systemic injection of TMT at the dose of 2.0 or 2.8 mg/kg produced a marked elevation in the level of plasma corticosterone that was both dose and time dependent. The MR agonist aldosterone had the ability to exacerbate TMT cytotoxicity in the dentate granule cell layer, whereas its antagonist spironolactone protected neurons from TMT cytotoxicity there. In contrast, the GR antagonist mifepristone exacerbated the TMT cytotoxicity. Taken together, our data suggest TMT cytotoxicity is oppositely regulated by GR and MR signals, being exacerbated by MR activation in adult mice.


► TMT-mediated neurotoxicity is exacerbated by a type I corticosterone receptor (mineralocorticoid receptor) agonist.
► TMT-mediated neurotoxicity is ameliorated by a type I corticosterone receptor (mineralocorticoid receptor) antagonist.
► TMT neurotoxicity is exacerbated by a type II corticosterone (glucocorticoid receptor) antagonist.
► Endogenous corticosterone functions as a multi-regulating factor in TMT-mediated neurotoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 511, Issue 2, 9 March 2012, Pages 116–119
نویسندگان
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