Visfatin induces neurite outgrowth in PC12 cells via ERK1/2 signaling pathway

► We investigated the neuritogenic effect of visfatin on PC12 cells. ► Visfatin expression was upregulated during cobalt chloride-induced neuritogenesis in PC12 cells. ► Visfatin induced neurite outgrowth in PC12 cells. ► Visfatin-induced outgrowth of neurites was mediated by ERK1/2 signaling pathway.