Developmental localization of NMDA receptors, Src and MAP kinases in mouse brain

► There is a developmental switch from NR2B to NR2A expression in synaptic membranes. ► NR1/NR2B is the main NMDA receptors (NMDAR) in extrasynaptic membranes at P7. ► NR2B phosphorylation at Y1472 and Y1252 is higher in adult synaptic membranes. ► At P7, phosphorylation of NR2B at Y1336 is associated with extrasynaptic NMDAR. ► STEP expression increases, while p38 decreases with development extrasynaptically.