Mutation screening of three Chinese families with genetic epilepsy with febrile seizures plus

► GEFS+ is a familial autosomal dominant condition characterized by genetic heterogeneity. ► Mutation in the majority of families with GEFS+ has not identified yet. ► The aim is to search for the gene responsible for GEFS+ in three Chinese families. ► No mutation was found in coding and noncoding regions of the four genes in three Chinese families. ► There are as yet undiscovered mechanisms underlying GEFS+.