کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4345163 | 1296707 | 2011 | 4 صفحه PDF | دانلود رایگان |

Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG + AG genotypes were more represented in the subgroup of early onset MD patients (p = 0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p = 0.04). Rs4680 genotype was associated with early onset BD as well (p = 0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.
► COMT gene variants are confirmed to be involved in mood disorders.
► COMT gene variants may be relevant for the age at onset of mood disorders.
► Bipolar and major depressive patients show similar effects of COMT gene variants.
Journal: Neuroscience Letters - Volume 498, Issue 3, 12 July 2011, Pages 218–221