کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4345163 1296707 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
COMT and age at onset in mood disorders: A replication and extension study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
COMT and age at onset in mood disorders: A replication and extension study
چکیده انگلیسی

Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG + AG genotypes were more represented in the subgroup of early onset MD patients (p = 0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p = 0.04). Rs4680 genotype was associated with early onset BD as well (p = 0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.


► COMT gene variants are confirmed to be involved in mood disorders.
► COMT gene variants may be relevant for the age at onset of mood disorders.
► Bipolar and major depressive patients show similar effects of COMT gene variants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 498, Issue 3, 12 July 2011, Pages 218–221
نویسندگان
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