Group II metabotropic glutamate receptors in the striatum of non-human primates: Dysregulation following chronic cocaine self-administration

► Group II metabotropic glutamate (mGluRs) are involved in the effects of cocaine. ► We studied the density of group II mGluRs following chronic cocaine in monkeys. ► We found higher levels of binding in the dorsal striatum, not the ventral striatum. ► Therefore the dorsal striatum may be more sensitive to the effects of cocaine. ► Treatments for cocaine that target these receptors may be efficacious.