Synaptotagmin1 synthesis induced by synaptic plasticity in mouse hippocampus through activation of nicotinic acetylcholine receptors

▶ Nicotinic agonists express a LTP-like facilitation in vivo in mouse hippocampus. ▶ Nicotine increases Syt1 mRNA level during LTP-like facilitation in hippocampus. ▶ Nicotine increases SYT1 protein level during LTP-like facilitation in hippocampus. ▶ Nicotine-enhanced SYT1 protein are mediated by activation of α7 and/or α4β2 nAChRs.