کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4345328 1296723 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice
چکیده انگلیسی

The beta-adrenergic system has been suggested to be involved in novelty detection and memory modulation. The present study aimed to investigate the role of beta-adrenergic receptors on novelty-based spatial recognition memory and exploratory behavior in mice using Y-maze test and open-field respectively. Mice were injected with three doses of beta-adrenergic receptor antagonist, propranolol (2, 10 and 20 mg/kg) or saline at three different time points (15 min prior to training, immediately after training and 15 min before test). The results showed that higher doses of propranolol (10 and 20 mg/kg) given before the training trial impaired spatial recognition memory while those injected at other two time points did not. A detailed analysis of exploratory behavior in open-field showed that lower dose (2 mg/kg) of propranolol reduced exploratory behavior of mice. Our findings indicate that higher dose of propranolol can impair acquisition of spatial information in the Y-maze without altering locomotion, suggesting that the beta-adrenergic system may be involved in modulating memory processes at the time of learning.


► The β-adrenergic system may involve in novelty dependent memory modulation.
► Spatial memory and novelty exploratory behavior were examined.
► Propranolol impaired acquisition in a dose-dependent manner.
► Decreased exploration and locomotion did not result in impaired memory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 498, Issue 2, 8 July 2011, Pages 133–137
نویسندگان
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