Targets for preventing epilepsy following cortical injury

► Successful prophylaxis will require a focus on more than one pathophysiological process. ► Choice of experimental model depends on the specific experimental issue to be addressed. ► Disinhibition and new excitatory synapse formation are key prophylactic targets. ► Enhancing trophic support by BDNF may “rescue” malfunctioning injured interneurons. ► Blockade of thrombospondin actions at a 2δ-1 receptors after injury is antiepileptogenic.