Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis

► The mammalian target of rapamycin (mTOR) pathway may be involved in epileptogenesis. ► mTOR inhibitors decrease seizures in animal models and patients with tuberous sclerosis. ► mTOR inhibitors may inhibit seizures in models of acquired injury-induced epilepsy. ► mTOR may mediate anticonvulsant or antiepileptogenic effects of the ketogenic diet.