کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4345451 | 1296731 | 2010 | 5 صفحه PDF | دانلود رایگان |
The purpose of this study was to investigate whether individuals at ultra-high risk (UHR) for psychosis and patients experiencing first-episode schizophrenia had impairments in visual information processing as indexed by the visual P300 event-related potential. Sixteen UHR individuals, 21 first-episode schizophrenia patients, and 16 healthy controls were included. Participants were asked to perform a visuospatial oddball task while undergoing an electroencephalogram. The UHR and first-episode groups showed reduced P300 amplitudes in comparison to healthy controls. P300 amplitudes were negatively correlated with severity of negative symptoms in both the UHR and first-episode groups. These results suggest that the visual P300 may be a neurobiological vulnerability marker, reflecting neurophysiological abnormalities associated with enduring negative symptoms in schizophrenia.
Research highlights▶ Ultra-high risk for psychosis showed reduced visual P300 amplitudes than controls. ▶ Visual P300 reduction in UHR was comparable to that in schizophrenia patients. ▶ P300 reduction was correlated with the severity of negative symptoms in both groups.
Journal: Neuroscience Letters - Volume 486, Issue 3, 17 December 2010, Pages 156–160