Local pretreatment with the cannabinoid CB1 receptor antagonist AM251 attenuates methamphetamine intra-accumbens self-administration

▶ We report the acquisition of intra-accumbens methamphetamine self administration in a rat model. ▶ Local pretreatment with AM251, cannabinoid receptor antagonist, reduced lever pressing for drug. ▶ Modulating the endocannabinoid system could provide a means to treat methamphetamine abuse.