Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice

Alzheimer's disease (AD) is a multifactorial disease that results in progressive neurodegeneration. Brain regions are differentially affected in AD. There is also an age-dependent effect on amyloid-beta peptide (Aβ) accumulation and neuroinflammation as disease progresses. In the TgCRND8 APP transgenic mouse model, levels of Aβ species and cytokines were examined as a function of brain region and age. A temporal sequence was observed whereby Aβ accumulation is followed by expression of IL-1β and eventually, of CXCL1, in the hippocampus and olfactory bulb but not the cortex. We have shown for the first time, in an APP mouse model, age and regional differences in Aβ accumulation and cytokine expression.

Research highlights
► Aβ species and cytokines were examined as a function of brain region and age.
► Regional differences in Aβ accumulation and cytokine levels were observed.
► Temporal and regional progression of Aβ accumulation in TgCRND8 parallels AD brain.
► Brain regions of high Aβ accumulation express elevated levels of IL-1β.
► CXCL1 levels were elevated following IL-1β elevation.