کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4345872 | 1296759 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Sphingosine 1-phosphate (S1P) is a pleiotropic mediator that is critically involved in the development of an inflammatory response in various pathological conditions. We hypothesize that during the course of multiple sclerosis (MS) development, chronic inflammation will result in the alteration of S1P levels in blood and cerebrospinal fluid (CSF). We evaluated S1P concentrations in blood and CSF obtained from 66 subjects, including 40 patients diagnosed with MS and 26 subjects of a control group that included patients diagnosed with idiopathic cephalgia and idiopathic (Bell's) facial nerve palsy. HPLC techniques were used to determine S1P levels. We found that S1P concentrations in blood of the MS subject group (361.7 ± 150.7 nM) did not differ from those of the control group (371.9 ± 142.5 nM). However, S1P concentrations in CSF of the MS group were significantly higher (p < 0.01) compared to the control group (2.2 ± 2.7 versus 0.69 ± 1.1 nM). The increase of S1P concentration in CSF of MS subjects suggests that this bioactive lipid is involved in chronic inflammation associated with MS and it may be useful to study S1P in a number of neurodegenerative diseases to provide better understanding of the mechanisms governing their development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 477, Issue 3, 25 June 2010, Pages 149-152
Journal: Neuroscience Letters - Volume 477, Issue 3, 25 June 2010, Pages 149-152
نویسندگان
Alina KuÅakowska, MaÅgorzata Å»endzian-Piotrowska, Marcin Baranowski, Tomasz KonoÅczuk, WiesÅaw Drozdowski, Jan Górski, Robert Bucki,