کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4345974 | 1296765 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Changes of some amino acid concentrations in the medial vestibular nucleus of conscious rats following acute hypotension Changes of some amino acid concentrations in the medial vestibular nucleus of conscious rats following acute hypotension](/preview/png/4345974.png)
Microdialysis and high performance liquid chromatography (HPLC) were used to measure the changes of certain amino acids in the medial vestibular nucleus (MVN) of conscious rats in order to understand whether those amino acids are involved in the regulation of blood pressure. Acute hypotension was induced by infusing sodium nitroprusside (SNP) into the femoral vein. In the control group, glutamate (Glu) release increased, though γ-aminobutyric acid (GABA) and taurine (Tau) release decreased in the MVN following acute hypotension. In the unilateral labyrinthectomy group, the levels of Glu, GABA, and Tau were unchanged in the ipsilateral MVN to the lesion following acute hypotension. Furthermore, in the contralateral MVN to the lesion, Glu release increased, and GABA and Tau release decreased following acute hypotension. These results suggest that SNP-induced acute hypotension can influence the activity of neurons in the MVN through afferent signals from peripheral vestibular receptors, and that certain amino acid transmitters in the MVN are involved in this process.
Journal: Neuroscience Letters - Volume 477, Issue 1, 14 June 2010, Pages 11–14