کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4346002 | 1296766 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat](/preview/png/4346002.png)
چکیده انگلیسی
The aim of this study evaluated the spinal anesthetic effect of verapamil and diltiazem. After rats were injected intrathecally with verapamil and diltiazem, dose-response curves were constructed. We evaluated the potency and duration of verapamil or diltiazem which compared with mepivacaine, a commonly used local anesthetic, in rats. Verapamil, diltiazem and mepivacaine produced a dose-dependent local anesthetic effect as spinal anesthesia. On a 50% effective dose (ED50) basis, the spinal anesthetic effect of verapamil was more potent than diltiazem or mepivacaine (PÂ <Â 0.01 for each comparison). On an equipotent basis (ED25, ED50, and ED75), the blockade duration of spinal anesthesia caused by diltiazem was longer than that caused by verapamil or mepivacaine (PÂ <Â 0.01 for each comparison). In summary, verapamil produced more potent spinal blockades, when compared with diltiazem or mepivacaine. Diltiazem demonstrated longer spinal blockades than did verapamil or mepivacaine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 482, Issue 1, 20 September 2010, Pages 76-80
Journal: Neuroscience Letters - Volume 482, Issue 1, 20 September 2010, Pages 76-80
نویسندگان
Yu-Wen Chen, Chin-Chen Chu, Yu-Chung Chen, Jhi-Joung Wang, Ching-Hsia Hung,